Efficacy of granulocyte-macrophage colony-stimulating factor in acquired alveolar proteinosis.

that both artemether and the closely related compound arteether induce a selective pattern of damage principally to the brain-stem nuclei involved in auditory processing. 3 If the prolongation of coma observed in our study and in the accompanying study from the Gambia was caused by neurotoxicity, then it was reversible. There was no associated neurologic deficit in survivors, and no evidence of auditory abnormalities. The incidence of neurologic sequelae in the Gambian trial was also similar in the two treatment groups. We believe that a definitive statement regarding the relative merits of artemether and quinine should await a systematic overview of many randomized, controlled trials. If this confirms that artemether treatment is associated with a lower mortality rate than quinine, and there is no associated increase in neurologic sequelae, then any effect on the duration of coma will have secondary importance. Dr. Newmark is correct; an error crept into the manuscript. The line should have read, “the correlated QT interval was prolonged to more than 0.5 second.”